Take your halved chicken breasts and place them in a mixing bowl. Pour in the buttermilk and hot sauce. Mix until the chicken is well-coated. Cover the bowl and allow the chicken to marinate in the refrigerator for at least an hour.
In a separate bowl, combine the all-purpose flour, cornstarch, seasoned salt, garlic powder, onion powder, Italian seasoning, and cayenne pepper. Stir until the ingredients are thoroughly mixed.
Remove the marinated chicken from the refrigerator. One piece at a time, allow any excess marinade to drip off the chicken, then dip each chicken piece into the flour mixture, ensuring it's fully coated. Set the breaded chicken pieces aside on a rack—place them in the fridge for about 15 minutes.
In a large, heavy-bottomed skillet or frying pan, add enough canola oil to fill the pan about halfway. Heat the oil over medium-high heat until it reaches 350 degrees Fahrenheit.
Carefully place the breaded chicken pieces into the hot oil. Fry them for about 4-5 minutes on each side, or until the chicken is golden brown and has an internal temperature of 165 degrees Fahrenheit.
Once the chicken is cooked, remove it from the oil using a slotted spoon or tongs, and place it on a wire rack or paper towel-lined plate to drain any excess oil.